Document Detail


Georges Marinesco and the early research in neuropathology.
MedLine Citation:
PMID:  19122036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To present the scientific contributions of Georges Marinesco (1863-1938) and place his achievements within the context of early neuropathology research. BACKGROUND: Neuropathology is a relatively recent medical field, its origins dating to the late 19th century. RESULTS: One of the most important neuroscientists of that period was the Romanian-born Georges Marinesco. He became a neurologist under Charcot's guidance at the Salpêtrière Hospital, in Paris. In 1892, Paul Blocq and Marinesco gave a first account of senile plaques, having used their pathologic skills in the examination of nine deceased epileptic patients. They did not, however, relate the plaques to dementia. Marinesco made discoveries in neuropathology which he described from a histopathologic perspective, and introduced new medical terms such as neuronophagia, chromatolysis, and medullomyoblastoma. He also drew correlations between clinical neurologic findings and morphology, for example in congenital cerebellar ataxia, syringomyelia, and parkinsonism. From 1899 he used cinematography as a medical research tool. CONCLUSION: Marinesco was a prolific researcher in the field of neuropathology, especially neurodegeneration but also in clinical neurology. He is now considered the founder of the modern Romanian school of neurology.
Authors:
O Buda; D Arsene; M Ceausu; D Dermengiu; G C Curca
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Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  72     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  AIM; IM    
Affiliation:
Mina Minovici National Institute of Legal Medicine, Sos. Vitan-Birzesti 9, 042122 Bucharest 4, Romania. octbuda@voxline.ro
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MeSH Terms
Descriptor/Qualifier:
History, 19th Century
Humans
Male
Nervous System Diseases / history*,  pathology*
Neurology / history*
Pathology / history*
Romania
Personal Name Subject
Personal Name Subject:
Georges Marinesco

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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