| Geometrical regularization of displacement fields for histological image registration. | |
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MedLine Citation:
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PMID: 17690003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article tackles the registration of 2-D biomedical images (histological sections, autoradiographs, cryosections, etc.). Our goal is to adequately match anatomical features of interest without inducing biologically improbable tissue distortions. We observe that the large variety of registration applications--3-D volume reconstruction, multimodal molecular mapping, etc.--induce a no less diverse set of requirements in terms of accuracy and robustness. In turn, these directly translate into regularization constraints on the deformation model, which should ideally be specifiable by the user. We propose an adaptive regularization approach where the rigidity constraints are informed by the registration application at hand and whose support is controlled by the geometry of the images to be registered. For each site of a sparse lattice over which a displacement field has been computed, our algorithm estimates, in a robust fashion, a rigid or affine transformation within a circular neighbourhood cut to fit the local geometry around the site. We investigate the behaviour of this technique and discuss its sensitivity to the rigidity parameter. |
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Authors:
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Alain Pitiot; Alexandre Guimond |
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Publication Detail:
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Type: Journal Article Date: 2007-06-30 |
Journal Detail:
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Title: Medical image analysis Volume: 12 ISSN: 1361-8423 ISO Abbreviation: Med Image Anal Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9713490 Medline TA: Med Image Anal Country: Netherlands |
Other Details:
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Languages: eng Pagination: 16-25 Citation Subset: IM |
Affiliation:
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Laboratory of Image and Data Analysis, Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. alain.pitiot@nottingham.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Brain Mapping / methods Histological Techniques Image Enhancement / methods Image Processing, Computer-Assisted / methods* Imaging, Three-Dimensional Mice |
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