Document Detail

Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia.
MedLine Citation:
PMID:  17847010     Owner:  NLM     Status:  MEDLINE    
The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.
Hui Li; Namita Mukherjee; Usha Soundararajan; Zsanett Tarnok; Csaba Barta; Shagufta Khaliq; Aisha Mohyuddin; Sylvester L B Kajuna; S Qasim Mehdi; Judith R Kidd; Kenneth K Kidd
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-08-24
Journal Detail:
Title:  American journal of human genetics     Volume:  81     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-10-30     Revised Date:  2010-09-16    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  842-6     Citation Subset:  IM    
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
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MeSH Terms
Alcohol Dehydrogenase / genetics*
Asia, Western
Asian Continental Ancestry Group / genetics
Base Sequence
DNA Primers / genetics
Gene Flow
Gene Frequency
Genetic Drift
Selection, Genetic
Grant Support
Reg. No./Substance:
0/DNA Primers; EC protein, human; EC Dehydrogenase
Comment In:
Am J Hum Genet. 2009 Jan;84(1):89-92; author reply 92-4   [PMID:  19124091 ]

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