Document Detail

Geographical distribution of optic nerve hypoplasia and septo-optic dysplasia in Northwest England.
MedLine Citation:
PMID:  16423603     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the distribution of septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH) in the Greater Manchester and Lancashire (GM&L) region of Northwest England, and to analyze occurrence by location and over time. STUDY DESIGN: A population-based incidence study was undertaken for cases of SOD/ONH from GM&L. Standardized incidence ratio (SIR) for each district, relationships between SIRs and possible geographically varying risk factors, and spatial and space-time clustering were analyzed. RESULTS: Eighty-seven cases had a confirmed diagnosis of ONH/SOD giving an incidence of 10.9/100,000 per year in GM&L. SIRs ranged widely but were significantly elevated (lower confidence limit >100) in three districts: 167%, 192%, and 198%, respectively. All three were high population density, inner-city locations. SIRs were significantly correlated with higher rates of unemployment (r = 0.49, P = .01), dependent children in non-earning households (r = 0.47, P = .02), underage conceptions (r = 0.46, P = .02), and underage pregnancies (r = 0.44, P = .03). There was no evidence of spatial or space-time clustering. CONCLUSIONS: The incidence of ONH/SOD in GM&L was higher than that reported elsewhere. Cases were more common in areas that had higher unemployment and teenage pregnancy rates.
Leena Patel; Richard J Q McNally; Elizabeth Harrison; I Christopher Lloyd; Peter E Clayton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  148     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  AIM; IM    
Academic Unit of Child Health, The University of Manchester, Booth Hall Children's Hospital, Manchester, United Kingdom.
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MeSH Terms
Age Factors
Child, Preschool
England / epidemiology
Optic Nerve Diseases / epidemiology*
Septo-Optic Dysplasia / epidemiology*
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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