Document Detail

Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
MedLine Citation:
PMID:  23136059     Owner:  NLM     Status:  MEDLINE    
Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical distribution and risk association of nucleotide sequence variations were analyzed. We found that the E6 genes of HPV58 variants were more conserved than E7. Thus, E6 is a more appropriate target for type-specific detection, whereas E7 is more appropriate for strain differentiation. The frequency of sequence variation varied geographically. Africa had significantly more isolates with E6-367A (D86E) but significantly less isolates with E6-203G, -245G, -367C (prototype-like) than other regions (p ≤ 0.003). E7-632T, -760A (T20I, G63S) was more frequently found in Asia, and E7-793G (T74A) was more frequent in Africa (p < 0.001). Variants with T20I and G63S substitutions at E7 conferred a significantly higher risk for cervical intraepithelial neoplasia grade III and invasive cervical cancer compared to other HPV58 variants (odds ratio = 4.44, p = 0.007). In conclusion, T20I and/or G63S substitution(s) at E7 of HPV58 is/are associated with a higher risk for cervical neoplasia. These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas.
Paul K S Chan; Chuqing Zhang; Jong-Sup Park; Karen K Smith-McCune; Joel M Palefsky; Lucia Giovannelli; Francois Coutlée; Samantha Hibbitts; Ryo Konno; Wannapa Settheetham-Ishida; Tang-Yuan Chu; Annabelle Ferrera; María Alejandra Picconi; Federico De Marco; Yin-Ling Woo; Tainá Raiol; Patricia Piña-Sánchez; Jeong-Hoon Bae; Martin C S Wong; Mike Z Chirenje; Tsitsi Magure; Anna-Barbara Moscicki; Alison N Fiander; Giuseppina Capra; Eun Young Ki; Yi Tan; Zigui Chen; Robert D Burk; Martin C W Chan; Tak-Hong Cheung; David Pim; Lawrence Banks
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-29
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  132     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-05-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2528-36     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 UICC.
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MeSH Terms
Capsid Proteins / genetics*
Cervical Intraepithelial Neoplasia / genetics*,  virology
Cervix Uteri / metabolism
DNA, Neoplasm / genetics
Follow-Up Studies
Genetic Variation / genetics*
International Agencies
Oncogene Proteins, Viral / genetics*
Papillomaviridae / genetics
Papillomavirus E7 Proteins / genetics*
Papillomavirus Infections / genetics*,  virology
Polymerase Chain Reaction
Risk Assessment
Tumor Markers, Biological / genetics*
Uterine Cervical Neoplasms / genetics*,  virology
Grant Support
R01 CA078527/CA/NCI NIH HHS; U01 CA078527/CA/NCI NIH HHS
Reg. No./Substance:
0/Capsid Proteins; 0/DNA, Neoplasm; 0/E6 protein, human papillomavirus type 58; 0/Oncogene Proteins, Viral; 0/Papillomavirus E7 Proteins; 0/Tumor Markers, Biological

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