Document Detail

Geographic variation in the incidence of myocardial calcification associated with acute myocardial infarction.
MedLine Citation:
PMID:  2744747     Owner:  NLM     Status:  MEDLINE    
There is reason to believe that calcium influx into heart muscle during acute myocardial infarction (AMI) can aggravate myocyte injury. Furthermore, the degree of such influx might correlate with the occurrence of microscopic myocyte calcification observed at autopsy. We have searched for evidence of myocyte calcification in hearts of patients found to have AMI at autopsy at the Veterans Administration Medical Center in Salt Lake City (SLCVA), a region with a low myocardial infection death rate, and at the George Washington University Medical Center in Washington, DC (GWUMC), a region with a high myocardial infection death rate. Of 23 consecutive cases examined under "blind" conditions at the GWUMC in which AMI was found, there were 15 instances of cardiac myocyte calcification observed in von Kossa-stained sections. Not a single example of myocyte calcification was found in 23 comparable cases at the SLCVA. The basis of this difference in myocyte calcification is unknown, but may be related to the fact that the Salt Lake City drinking water contains a higher level of magnesium, which is known to protect against soft tissue calcification, than does that of Washington, DC. This may be the basis for the apparent protection that dietary magnesium exerts against myocardial infarction death.
S Bloom; L Peric-Golia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human pathology     Volume:  20     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-22     Completed Date:  1989-08-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  726-31     Citation Subset:  IM    
Department of Pathology, George Washington University Medical Center, Washington, DC.
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MeSH Terms
African Continental Ancestry Group
Calcinosis / complications,  epidemiology*,  pathology
District of Columbia
European Continental Ancestry Group
Middle Aged
Myocardial Infarction / complications,  epidemiology*,  pathology
Myocardium / pathology
Grant Support
Reg. No./Substance:
7439-95-4/Magnesium; 7440-70-2/Calcium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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