Document Detail

Geographic patterns of inversion polymorphisms in a wild African rodent, Mastomys erythroleucus.
MedLine Citation:
PMID:  19812611     Owner:  NLM     Status:  MEDLINE    
By suppressing recombination and reducing gene flow, chromosome inversions favor the capture and protection of advantageous allelic combinations, leading to adaptive polymorphisms. However, studies in non-model species remain scarce. Here we investigate the distribution of inversion polymorphisms in the multimammate rat Mastomys erythroleucus in West Africa. More than 270 individuals from 52 localities were karyotyped using G-bands and showed widespread polymorphisms involving four chromosome pairs. No significant deviations from Hardy-Weinberg equilibrium were observed either through space or time, nor were differences retrieved in viability or sex contribution between cytotypes. The distribution of chromosomal variation, however, showed perfect congruence with that of mtDNA-based phylogeographic clades. Thus, inversion diversity patterns in M. erythroleucus appeared more related to historical and/or demographic processes than to climate-based adaptive features. Using cross-species chromosome painting and G-banding analyses to identify homologous chromosomes in related out-group species, we proposed a phylogenetic scenario that involves ancestral-shared polymorphisms and subsequent lineage sorting during expansion/contraction of West African savannas. Our data suggest that long-standing inversion polymorphisms may act as regions in which adaptation genes may accumulate (nucleation model).
G Dobigny; J Catalan; P Gauthier; P C M O'Brien; C Brouat; K B?; C Tatard; M A Ferguson-Smith; J M Duplantier; L Granjon; J Britton-Davidian
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-07
Journal Detail:
Title:  Heredity     Volume:  104     ISSN:  1365-2540     ISO Abbreviation:  Heredity     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity     Country:  England    
Other Details:
Languages:  eng     Pagination:  378-86     Citation Subset:  IM    
Institut de Recherche pour le D?veloppement, Centre de Biologie pour la Gestion des Populations (UMR IRD/INRA/CIRAD/Montpellier SupAgro), Montferrier-sur-Lez, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Africa, Western
Animals, Wild / genetics
Chromosome Inversion* / genetics
Chromosome Painting
Gene Frequency
Murinae / genetics*
Polymorphism, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Contrasting relationships between the diversity of candidate genes and variation of bud burst in nat...
Next Document:  Contrasting modes for loss of pungency between cultivated and wild species of Capsicum.