Document Detail

Geographic pattern of genetic variation in the fox tapeworm Echinococcus multilocularis.
MedLine Citation:
PMID:  19651237     Owner:  NLM     Status:  MEDLINE    
Intraspecific genetic variation of Echinococcus multilocularis, the etiologic agent of human alveolar echinococcosis, has been evaluated among 76 geographic isolates from Europe, Asia and North America by using sequence data of mitochondrial and nuclear DNA. Relatively low genetic variation was found only in the mitochondrial DNA sequence consisting of 3 protein-coding genes. Pairwise divergence among the resultant 18 haplotypes ranged from 0.03 to 1.91%. Phylogenetic trees and parsimony network of these haplotypes depicted a geographic division into European, Asian and North American clades, but 1 haplotype from Inner Mongolia was unrelated to other haplotypes. The coexistence of the Asian and North American haplotypes could be seen, particularly on the St. Lawrence Island in the Bering Sea. These data suggest an evolutionary scenario in which distinct parasite populations derived from glacial refugia have been maintained by indigenous host mammals. The nuclear DNA sequence for the immunodominant B cell epitope region of ezrin/radixin/moesin-like protein (elp) was extremely conservative, indicating that the elp antigen is available for immunodiagnosis in any endemic areas.
Minoru Nakao; Ning Xiao; Munehiro Okamoto; Tetsuya Yanagida; Yasuhito Sako; Akira Ito
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-03
Journal Detail:
Title:  Parasitology international     Volume:  58     ISSN:  1873-0329     ISO Abbreviation:  Parasitol. Int.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708549     Medline TA:  Parasitol Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  384-9     Citation Subset:  IM    
Department of Parasitology, Asahikawa Medical College, Asahikawa, Hokkaido 078-8510, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB461395;  AB461396;  AB461397;  AB461398;  AB461399;  AB461400;  AB461401;  AB461402;  AB461403;  AB461404;  AB461405;  AB461406;  AB461407;  AB461408;  AB461409;  AB461410;  AB461411;  AB461412;  AB461413;  AB461414;  AB461415;  AB461416;  AB461417;  AB461418;  AB461419;  AB461420;  AB477009;  AB477010;  AB477011;  AB477012
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MeSH Terms
Antigens, Helminth / genetics
Antigens, Surface / genetics
Base Sequence
DNA, Mitochondrial / genetics
Echinococcosis / parasitology,  veterinary*
Echinococcus multilocularis / classification,  genetics*
Evolution, Molecular
Foxes / parasitology*
Genetic Variation*
Molecular Sequence Data
North America
Reg. No./Substance:
0/Antigens, Helminth; 0/Antigens, Surface; 0/DNA, Mitochondrial; 0/Elp protein, Echinococcus multilocularis

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