Document Detail


Geographic pattern of genetic variation in the fox tapeworm Echinococcus multilocularis.
MedLine Citation:
PMID:  19651237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraspecific genetic variation of Echinococcus multilocularis, the etiologic agent of human alveolar echinococcosis, has been evaluated among 76 geographic isolates from Europe, Asia and North America by using sequence data of mitochondrial and nuclear DNA. Relatively low genetic variation was found only in the mitochondrial DNA sequence consisting of 3 protein-coding genes. Pairwise divergence among the resultant 18 haplotypes ranged from 0.03 to 1.91%. Phylogenetic trees and parsimony network of these haplotypes depicted a geographic division into European, Asian and North American clades, but 1 haplotype from Inner Mongolia was unrelated to other haplotypes. The coexistence of the Asian and North American haplotypes could be seen, particularly on the St. Lawrence Island in the Bering Sea. These data suggest an evolutionary scenario in which distinct parasite populations derived from glacial refugia have been maintained by indigenous host mammals. The nuclear DNA sequence for the immunodominant B cell epitope region of ezrin/radixin/moesin-like protein (elp) was extremely conservative, indicating that the elp antigen is available for immunodiagnosis in any endemic areas.
Authors:
Minoru Nakao; Ning Xiao; Munehiro Okamoto; Tetsuya Yanagida; Yasuhito Sako; Akira Ito
Related Documents :
23505017 - Effects of late quaternary climate change on palearctic shrews.
24091427 - Moose body mass variation revisited: disentangling effects of environmental conditions ...
11903557 - Haplotype frequency distribution and discriminatory power of two mtdna fragments in a m...
23533607 - Phylogenetic analysis reveals a cryptic species blastomyces gilchristii, sp. nov. withi...
1908397 - Mutational analysis of the drosophila miniature-dusky (m-dy) locus: effects on cell siz...
21072187 - Evidence for significant overlap between common risk variants for crohn's disease and a...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-03
Journal Detail:
Title:  Parasitology international     Volume:  58     ISSN:  1873-0329     ISO Abbreviation:  Parasitol. Int.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708549     Medline TA:  Parasitol Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  384-9     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Asahikawa Medical College, Asahikawa, Hokkaido 078-8510, Japan. nakao@asahikawa-med.ac.jp
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB461395;  AB461396;  AB461397;  AB461398;  AB461399;  AB461400;  AB461401;  AB461402;  AB461403;  AB461404;  AB461405;  AB461406;  AB461407;  AB461408;  AB461409;  AB461410;  AB461411;  AB461412;  AB461413;  AB461414;  AB461415;  AB461416;  AB461417;  AB461418;  AB461419;  AB461420;  AB477009;  AB477010;  AB477011;  AB477012
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Helminth / genetics
Antigens, Surface / genetics
Asia
Base Sequence
DNA, Mitochondrial / genetics
Echinococcosis / parasitology,  veterinary*
Echinococcus multilocularis / classification,  genetics*
Europe
Evolution, Molecular
Foxes / parasitology*
Genetic Variation*
Haplotypes
Humans
Molecular Sequence Data
North America
Phylogeny
Chemical
Reg. No./Substance:
0/Antigens, Helminth; 0/Antigens, Surface; 0/DNA, Mitochondrial; 0/Elp protein, Echinococcus multilocularis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogen...
Next Document:  Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes.