| Gentamycin inhibits the growth of Malassezia pachydermatis in culture. | |
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MedLine Citation:
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PMID: 20149702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Malassezia pachydermatis is a yeast of importance in both veterinary and human medicine. AIMS: To know if M. pachydermatis grow on mycological media with high concentrations of gentamycin. METHODS: Twenty M. pachydermatis strains were streaked on Sabouraud Dextrose Agar plates with different concentrations of gentamycin. RESULTS: All isolates were inhibited when high concentrations of gentamycin were added. CONCLUSIONS: The use of plates with high concentrations of gentamycin can lead to some important misdiagnoses: firstly, false-negative cultures, and secondly, an erroneous classification of M. pachydermatis as a lipid-dependent species. Moreover, all of this could be useful in two therapeutic fields: i) in animals, topical gentamycin could be an efficacious treatment for a disease such as external otitis in dogs; ii) in humans, we hypothesize that gentamycin could be regarded as a possible therapy ("antibiotic-lock") for catheter-associated Malassezia spp. infections. |
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Authors:
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Carmen Aspíroz; Yolanda Gilaberte; Antonio Rezusta; Teun Boekhout; M A Carmen Rubio |
Publication Detail:
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Type: Journal Article Date: 2010-02-10 |
Journal Detail:
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Title: Revista iberoamericana de micología Volume: 27 ISSN: 1130-1406 ISO Abbreviation: Rev Iberoam Micol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-06-22 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 9425531 Medline TA: Rev Iberoam Micol Country: Spain |
Other Details:
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Languages: eng Pagination: 20-1 Citation Subset: IM |
Copyright Information:
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2009 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Microbiología, Hospital Royo Villanova, Zaragoza, Spain. carmenaspiroz@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Culture Media / pharmacology Dermatomycoses / microbiology, veterinary Dog Diseases / microbiology Dogs / microbiology Drug Evaluation, Preclinical Gentamicins / pharmacology* Humans Malassezia / drug effects*, growth & development, isolation & purification Otitis Externa / microbiology, veterinary |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Gentamicins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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