Document Detail

Gentamycin inhibits the growth of Malassezia pachydermatis in culture.
MedLine Citation:
PMID:  20149702     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Malassezia pachydermatis is a yeast of importance in both veterinary and human medicine.
AIMS: To know if M. pachydermatis grow on mycological media with high concentrations of gentamycin.
METHODS: Twenty M. pachydermatis strains were streaked on Sabouraud Dextrose Agar plates with different concentrations of gentamycin.
RESULTS: All isolates were inhibited when high concentrations of gentamycin were added.
CONCLUSIONS: The use of plates with high concentrations of gentamycin can lead to some important misdiagnoses: firstly, false-negative cultures, and secondly, an erroneous classification of M. pachydermatis as a lipid-dependent species. Moreover, all of this could be useful in two therapeutic fields: i) in animals, topical gentamycin could be an efficacious treatment for a disease such as external otitis in dogs; ii) in humans, we hypothesize that gentamycin could be regarded as a possible therapy ("antibiotic-lock") for catheter-associated Malassezia spp. infections.
Carmen Aspíroz; Yolanda Gilaberte; Antonio Rezusta; Teun Boekhout; M A Carmen Rubio
Publication Detail:
Type:  Journal Article     Date:  2010-02-10
Journal Detail:
Title:  Revista iberoamericana de micología     Volume:  27     ISSN:  1130-1406     ISO Abbreviation:  Rev Iberoam Micol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-22     Revised Date:  2012-05-01    
Medline Journal Info:
Nlm Unique ID:  9425531     Medline TA:  Rev Iberoam Micol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  20-1     Citation Subset:  IM    
Copyright Information:
2009 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.
Servicio de Microbiología, Hospital Royo Villanova, Zaragoza, Spain.
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MeSH Terms
Culture Media / pharmacology
Dermatomycoses / microbiology,  veterinary
Dog Diseases / microbiology
Dogs / microbiology
Drug Evaluation, Preclinical
Gentamicins / pharmacology*
Malassezia / drug effects*,  growth & development,  isolation & purification
Otitis Externa / microbiology,  veterinary
Reg. No./Substance:
0/Culture Media; 0/Gentamicins

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