| Gentamicin and penicillin in the treatment of severe respiratory infections. | |
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MedLine Citation:
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PMID: 375433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combination of penicillin and gentamicin has been used for severely ill patients in a respiratory intensive care ward. It has been shown that predictable mean blood levels of gentamicin can be obtained in these patients by relating the dose to surface area (60 mg/m2/8 h). When renal function was initially normal it did not deteriorate during the course of therapy (10 days); gentamicin assays are not essential for safe treatment. In patients with renal failure, increasing the interval between doses also resulted in satisfactory levels, but close monitoring of the serum creatinine level is considered necessary. No clinical difference could be detected when gentamicin was given by constant or intermittent infusion. |
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Authors:
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J P Wright; P D Potgieter; A A Forder; P Botha; G Brinkworth; G Elisha; A D Ferguson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 55 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-07-28 Completed Date: 1979-07-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 197-200 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Trials as Topic Creatinine / blood Drug Therapy, Combination Gentamicins / administration & dosage*, blood Humans Infusions, Parenteral Injections, Intravenous Kidney Failure, Chronic / complications Lung Diseases, Obstructive / drug therapy Middle Aged Penicillins / administration & dosage* Pneumonia / drug therapy Respiratory Distress Syndrome, Adult / drug therapy Respiratory Tract Diseases / drug therapy* Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 0/Penicillins; 57-13-6/Urea; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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