| Gentamicin interval in newborn infants as determined by renal function and postconceptional age. | |
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MedLine Citation:
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PMID: 1768575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the relationship between gentamicin pharmacokinetics and glomerular filtration rate in newborn infants to estimate the appropriate interval of administration in neonates with renal insufficiency. Gentamicin half-life (Gt1/2) could be predicted from plasma creatinine concentration (PCr) (r = 0.78); the prediction was minimally but significantly increased (r = 0.81) by adding post-conceptional age to a multiple regression analysis. Infants with a postconceptional age of 29 weeks or more and a PCr of 1 mg/dl or more had significantly greater through and peak gentamicin levels than those with a PCr less than 1 mg/dl. If gentamicin is indicated in a patient with renal insufficiency, the interval of administration should be 2-3 Gt1/2, which can be estimated from PCr (Gt1/2 = 2.0 + 7.7 PCr). The interval can then be adjusted according to peak and trough gentamicin levels. |
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Authors:
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L P Brion; A R Fleischman; G J Schwartz |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 5 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-02-27 Completed Date: 1992-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 675-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Creatinine
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blood Drug Administration Schedule Gentamicins / administration & dosage, pharmacokinetics* Gestational Age Glomerular Filtration Rate Humans Infant, Newborn Injections, Intramuscular Kidney / physiopathology* Kidney Failure, Acute / metabolism*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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