Document Detail

Gentamicin interval in newborn infants as determined by renal function and postconceptional age.
MedLine Citation:
PMID:  1768575     Owner:  NLM     Status:  MEDLINE    
We evaluated the relationship between gentamicin pharmacokinetics and glomerular filtration rate in newborn infants to estimate the appropriate interval of administration in neonates with renal insufficiency. Gentamicin half-life (Gt1/2) could be predicted from plasma creatinine concentration (PCr) (r = 0.78); the prediction was minimally but significantly increased (r = 0.81) by adding post-conceptional age to a multiple regression analysis. Infants with a postconceptional age of 29 weeks or more and a PCr of 1 mg/dl or more had significantly greater through and peak gentamicin levels than those with a PCr less than 1 mg/dl. If gentamicin is indicated in a patient with renal insufficiency, the interval of administration should be 2-3 Gt1/2, which can be estimated from PCr (Gt1/2 = 2.0 + 7.7 PCr). The interval can then be adjusted according to peak and trough gentamicin levels.
L P Brion; A R Fleischman; G J Schwartz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  5     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  675-9     Citation Subset:  IM    
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461.
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MeSH Terms
Creatinine / blood
Drug Administration Schedule
Gentamicins / administration & dosage,  pharmacokinetics*
Gestational Age
Glomerular Filtration Rate
Infant, Newborn
Injections, Intramuscular
Kidney / physiopathology*
Kidney Failure, Acute / metabolism*,  physiopathology
Reg. No./Substance:
0/Gentamicins; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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