Document Detail

Gentamicin disposition in asphyxiated newborns: relationship to mean arterial blood pressure and urine output.
MedLine Citation:
PMID:  7162873     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the effects of changes in renal function on gentamicin disposition following perinatal asphyxia. Gentamicin pharmacokinetics, renal function, mean arterial pressure (MAP) and five-minute Apgar scores were determined in 80 preterm infants admitted to two neonatal intensive care units over an 18 month period. A 2.5 mg/kg dose of gentamicin was infused intravascularly over 20 to 30 minutes in a retrograde fashion. The gentamicin half-life and clearance were prolonged in asphyxiated infants. For the asphyxiated infants gentamicin half-life increased and urine output decreased with a significant correlation (r = -0.66, p less than 0.05). Gentamicin clearance and urine output in the asphyxia group correlated with MAP (r = +0.67, p = 0.07). In non-asphyxia infants no such correlation was seen. This study does not distinguish between asphyxia-induced or gentamicin-induced nephrotoxicity following gentamicin therapy. We suggest that gentamicin concentrations be closely monitored in asphyxiated newborns who demonstrate compromised renal function.
C A Friedman; B R Parks; J E Rawson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pharmacology (New York, N.Y.)     Volume:  2     ISSN:  0270-322X     ISO Abbreviation:  Pediatr Pharmacol (New York)     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8400778     Medline TA:  Pediatr Pharmacol (New York)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
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MeSH Terms
Asphyxia Neonatorum / metabolism*,  physiopathology
Birth Weight
Blood Pressure*
Gentamicins / metabolism*
Infant, Newborn
Kidney / physiopathology*
Reg. No./Substance:

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