Document Detail

Gentamicin-collagen sponge for local applications. 10 cases of chronic osteomyelitis followed for 1 year.
MedLine Citation:
PMID:  1767654     Owner:  NLM     Status:  MEDLINE    
A bovine collagen sponge containing gentamicin was applied locally in 10 patients with chronic osteomyelitis who were then followed for 1 year postoperatively. No adverse effects or recurrence of infections was observed. The release of gentamicin from the sponge was more complete and rapid than has been reported with polymethyl methacrylate (PMMA) beads. Compared with previous reports on PMMA beads, a much higher gentamicin concentration in the wound exudate can be expected after implantation of the collagen sponge, which is easy to apply and does not require a second operation for removal.
T Ipsen; P S Jørgensen; V Damholt; C Tørholm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  62     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  592-4     Citation Subset:  IM    
University Department of Orthopedics, Odense, Denmark.
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MeSH Terms
Administration, Topical
Drug Carriers
Follow-Up Studies
Gentamicins / administration & dosage*
Middle Aged
Osteomyelitis / drug therapy*,  physiopathology
Prospective Studies
Wound Healing / drug effects
Reg. No./Substance:
0/Drug Carriers; 0/Gentamicins; 9007-34-5/Collagen

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