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Gentamicin In Combination With Ascorbic Acid Regulates The Severity Of Staphylococcus Aureus Infection Induced Septic Arthritis In Mice.
MedLine Citation:
PMID:  22924656     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To study the effects of gentamicin in combination with ascorbic acid on septic arthritis, mice were infected with Staphylococcus aureus (S. aureus) and treated with gentamicin, which was given at 5mg/kg after 24hr of infection, followed by ascorbic acid, given at 20mg/kg body weight after 2 hours of gentamicin treatment. Mice were sacrificed at 3, 9, 15 days post infection (dpi). Combined treatment of infected mice with gentamicin and ascorbic acid eradicated the bacteria from the blood, spleen and synovial tissue and showed a significant gross reduction in arthritis, reduced serum levels of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). S. aureus infected mice have demonstrated the disturbed antioxidant status measured in terms of cellular anti-oxidants like reduced glutathione and anti-oxidant enzymes such as superoxide dismutase (SOD) and Catalase. The same were ameliorated when the animals were co-treated with Gentamicin along with ascorbic acid.
Authors:
Pinky Mal; Sulagna Dutta; Debasish Bandyopadhyay; Kallol Dutta; Anirban Basu; Biswadev Bishayi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  -     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Physiology, Immunology laboratory. University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta-700009, West Bengal, India Department of Physiology, Oxidative Stress and Free Radical Biology Laboratory. University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta-700009, West Bengal, India National Brain Research Centre, Manesar, Haryana 122050, India.
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