Document Detail


Genotyping of macerated stillborn fetuses.
MedLine Citation:
PMID:  2003544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is generally impossible to collect blood or to culture tissue from a macerated stillborn fetus. Accurate genotyping of such a fetus may, however, be critical for the diagnosis of genetic diseases and appropriate genetic counseling. In the East Flanders Prospective Twin Study, placental tissue of twin and triplet sets, in some of which one or both members were stillborn and macerated, has been stored at -20 degrees C. Of all these fetuses, sex and zygosity could be determined accurately on the placental deoxyribonucleic acid. We tested the possibility of nongenetic changes in deoxyribonucleic acid that result from maceration or tissue degradation over time in storage on placental samples from monochorionic twins in which only one member was stillborn and macerated. The deoxyribonucleic acid variants in these monozygotic twins were identical whether or not either cotwin was macerated. Thus deoxyribonucleic acid variants can be determined accurately on the placental tissue of macerated fetuses, even after prolonged freezing.
Authors:
C Derom; R Vlietinck; R Derom; C Boklage; M Thiery; H Van den Berghe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  164     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  797-800     Citation Subset:  AIM; IM    
Affiliation:
Centre of Human Genetics, Catholic University of Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
DNA / analysis*
Female
Fetal Death / genetics*
Genotype
Humans
Pregnancy
Twins
Grant Support
ID/Acronym/Agency:
HD-22507/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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