Document Detail


Genotyping of human platelet antigens in ethnic Northeastern Thais by the polymerase chain reaction-sequence specific primer technique.
MedLine Citation:
PMID:  11215863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human platelet antigens (HPA) are important in neonatal alloimmune thrombocytopenia (NAITP), post-transfusion purpura (PTP), refractoriness to platelet transfusion therapy and population genetics. The distribution of HPA in a Northeast Thai population was studied. 300 healthy, unrelated, and ethnic Northeastern Thais were randomly selected. Using the polymerase chain reaction-sequence specific primer technique (PCR-SSP), the frequency of HPA-1, -2, -3, -4, -5 and -6 were determined. The phenotype frequencies were 100 per cent for HPA-1a, 4a, 5a, and 6a. For HPA-1b, 2a, 2b, 3a, 3b, 5b and 6b, the frequencies were 5.7, 99.7, 12.3, 78.0, 71.3, 7.3 and 3.0 per cent, respectively. The HPA-4b was not found. The HPA frequencies in our subjects were quite similar to other Asian populations but were different from Caucasians. The distribution of HPA genotypes encountered in our study indicate that HPA-1a, -4a, -4b, -5a and -6a will not be involved in NAITP, PTP and refractoriness to platelet transfusion therapy in Northeastern Thais. Moreover, HPA-1b, -2a, -2b, -3a, -3b, -5b and -6b may induce alloantibodies in these patients.
Authors:
A V Romphruk; J Akahat; P Srivanichrak; C Puapairoj; A Romphruk; C Leelayuwat
Related Documents :
145673 - Selection of compatible platelet donors: a prospective evaluation of three cross-matchi...
23323973 - The complex transcriptional landscape of the anucleate human platelet.
11330783 - Radionuclide venography and labeled platelets in deep venous thrombosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  83     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1333-9     Citation Subset:  IM    
Affiliation:
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antigens, Human Platelet / genetics*
Base Sequence
Ethnic Groups
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction / methods*
Purpura, Thrombocytopenic, Idiopathic / genetics
Thailand
Chemical
Reg. No./Substance:
0/Antigens, Human Platelet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A multicenter randomized double-blind comparison of remifentanil and alfentanil during total intrave...
Next Document:  Radiofrequency catheter ablation in pediatrics: experience at Siriraj Hospital.