Document Detail

Genotyping of human platelet antigens in ethnic Northeastern Thais by the polymerase chain reaction-sequence specific primer technique.
MedLine Citation:
PMID:  11215863     Owner:  NLM     Status:  MEDLINE    
Human platelet antigens (HPA) are important in neonatal alloimmune thrombocytopenia (NAITP), post-transfusion purpura (PTP), refractoriness to platelet transfusion therapy and population genetics. The distribution of HPA in a Northeast Thai population was studied. 300 healthy, unrelated, and ethnic Northeastern Thais were randomly selected. Using the polymerase chain reaction-sequence specific primer technique (PCR-SSP), the frequency of HPA-1, -2, -3, -4, -5 and -6 were determined. The phenotype frequencies were 100 per cent for HPA-1a, 4a, 5a, and 6a. For HPA-1b, 2a, 2b, 3a, 3b, 5b and 6b, the frequencies were 5.7, 99.7, 12.3, 78.0, 71.3, 7.3 and 3.0 per cent, respectively. The HPA-4b was not found. The HPA frequencies in our subjects were quite similar to other Asian populations but were different from Caucasians. The distribution of HPA genotypes encountered in our study indicate that HPA-1a, -4a, -4b, -5a and -6a will not be involved in NAITP, PTP and refractoriness to platelet transfusion therapy in Northeastern Thais. Moreover, HPA-1b, -2a, -2b, -3a, -3b, -5b and -6b may induce alloantibodies in these patients.
A V Romphruk; J Akahat; P Srivanichrak; C Puapairoj; A Romphruk; C Leelayuwat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  83     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1333-9     Citation Subset:  IM    
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
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MeSH Terms
Antigens, Human Platelet / genetics*
Base Sequence
Ethnic Groups
Gene Frequency
Polymerase Chain Reaction / methods*
Purpura, Thrombocytopenic, Idiopathic / genetics
Reg. No./Substance:
0/Antigens, Human Platelet

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