| Genotyping human platelet alloantigens (HPA 1-5) in Saudis from Eastern Province, Saudi Arabia. | |
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MedLine Citation:
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PMID: 11370330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we report for the first time the distribution of human platelet alloantigens (HPA) in Saudis. These antigens are implicated in the pathophysiology of alloimmune thrombocytopenia. We collected blood samples from 84 healthy male Saudi blood donors. DNA isolated by salting-out and ethanol precipitation was amplified for genes HPA 1-5 using the polymerase chain reaction/sequence specific primer method. We found high HPA-1 polymorphism similar to Caucasians. HPA-4 polymorphism in Saudis was, however, greater than in Caucasians, and more similar to that of the Japanese. These results suggest that both these two HPA systems may be clinically important in Saudis. |
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Authors:
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I al-Sheikh; A Rahi; M al-Khalifa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ Volume: 6 ISSN: 1020-3397 ISO Abbreviation: East. Mediterr. Health J. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2001-05-23 Completed Date: 2001-07-05 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9608387 Medline TA: East Mediterr Health J Country: Egypt |
Other Details:
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Languages: eng Pagination: 168-75 Citation Subset: IM |
Affiliation:
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Department of Pathology, College of Medicine, King Faisal University, Al-Khobar, Saudi Arabia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Human Platelet
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genetics* Blood Donors European Continental Ancestry Group / genetics Gene Frequency / genetics* Genotype Humans Male Platelet Membrane Glycoproteins / classification, genetics* Polymerase Chain Reaction Polymorphism, Genetic / genetics* Saudi Arabia |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Human Platelet; 0/Platelet Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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