Document Detail


Genotypical diversity of HIV clades and central nervous system impairment.
MedLine Citation:
PMID:  22297889     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The central nervous system (CNS) and the immune system are considered major target organs for HIV infection. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV associated dementia, vacuolar myelopathy and involvement of the peripheral nervous system. Changes in diagnosis and clinical management have changed the aspect of HIV infection so that it is no longer a fatal disease, and has become a chronic disease requiring sustained medical management. After HAART the incidence of most opportunistic infections, including those affecting the CNS, has dropped markedly. Some studies suggest that neurological involvement of infected patient occur with different frequency, depending on HIV subtype involved in the infection. Subtype C may have reduced neuroinvasive capacity, possibly due to its different primary conformation of HIV transactivating regulatory protein (Tat), involved in monocyte chemotaxis. This review focus on physiopathologic aspects of HIV infection in CNS and its correlation with HIV clades.
Authors:
Indianara Rotta; Sérgio Monteiro de Almeida
Related Documents :
16555289 - Picornavirus infections in children diagnosed by rt-pcr during longitudinal surveillanc...
22311149 - Predicting depression in mothers with and without hiv: the role of social support and f...
22698629 - Protease inhibitor treatment effect on aortic stiffness in normotensive patients with h...
22312169 - Human immunodeficiency virus disease severity, psychiatric symptoms, and functional out...
17828689 - Real-time polymerase chain reaction detection of methicillin-resistant staphylococcus a...
22590899 - Regional patterns and correlates of hiv voluntary counselling and testing among youths ...
22591479 - Hiv-1 protease cleavage site prediction based on two stage feature selection method.
24419349 - Inhibition of hepatitis c virus replication by gs-6620, a potent c-nucleoside monophosp...
20154579 - Survival of hiv-infected patients with compensated liver cirrhosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  69     ISSN:  1678-4227     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  964-72     Citation Subset:  IM    
Affiliation:
Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rethinking the neurological examination II: dynamic balance assessment.
Next Document:  Meningeal carcinomatosis in solid tumors.