| Genotypic and clinicopathological characterization of Kaposi's sarcoma-associated herpesvirus infection in Japan. | |
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MedLine Citation:
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PMID: 20087946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kaposi's sarcoma-associated herpesvirus (KSHV) is related causally to Kaposi's sarcoma, primary effusion lymphoma, and a subset of cases of multicentric Castleman's disease. As the numbers of acquired immunodeficiency syndrome (AIDS) patients have increased, KSHV-associated diseases have also increased in Japan. Sporadic cases of classic Kaposi's sarcoma have also been reported in Japan. In the present study, the clinicopathological characteristics of 75 samples, comprising 68 cases of Kaposi's sarcoma, 5 cases of primary effusion lymphoma, and 5 cases of multicentric Castleman's disease were investigated. All of these cases were positive for KSHV by immunohistochemistry or PCR analysis. All fifty-two of the AIDS-associated Kaposi's sarcoma cases were males, whereas 7 of the 13 non-AIDS-associated Kaposi's sarcoma cases were females. The mean age of patients with AIDS-associated Kaposi's sarcoma or primary effusion lymphoma was 46 years, whereas the mean age of patients with non-AIDS-associated Kaposi's sarcoma or primary effusion lymphoma was 71.8 and 97.5, respectively. KSHV genotypes were determined based on the sequence of variable region 1 in the K1 gene. Genotypes A and C of KSHV were detected in both AIDS- and non-AIDS-associated Kaposi's sarcoma. Genotype A was detected more frequently in AIDS-associated cases than non-AIDS-associated cases, suggesting that genotype C is broadly distributed in Japan, and genotype A spreads among AIDS patients. Genotype D was detected only in non-AIDS-associated Kaposi's sarcoma. These data confirmed the difference between AIDS- and non-AIDS-associated KSHV diseases with regard to age of onset, gender, and genotypes in Japan. J. Med. Virol. 82:400-406, 2010. (c) 2010 Wiley-Liss, Inc. |
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Authors:
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Takayuki Kanno; Yuko Sato; Tomoyuki Nakamura; Kouta Sakamoto; Tetsutaro Sata; Harutaka Katano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical virology Volume: 82 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 400-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over DNA, Viral / analysis, genetics Female Genotype Giant Lymph Node Hyperplasia / pathology*, virology HIV Infections / complications Herpesviridae Infections / pathology*, virology Herpesvirus 8, Human / classification, genetics, isolation & purification* Humans Immunohistochemistry / methods Japan / epidemiology Lymphoma, Primary Effusion / pathology*, virology Male Middle Aged Molecular Epidemiology Polymerase Chain Reaction / methods Sarcoma, Kaposi / pathology*, virology Sex Factors Viral Proteins / analysis Young Adult |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Viral Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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