Document Detail


Genotypic HIV type-1 drug resistance among patients with immunological failure to first-line antiretroviral therapy in south India.
MedLine Citation:
PMID:  19918105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: HIV type-1 (HIV-1) monitoring in resource-limited settings relies on clinical and immunological assessment. The objective of this study was to study the frequency and pattern of reverse transcriptase (RT) drug resistance among patients with immunological failure (IF) to first-line therapy.
METHODS: A cross-sectional study of 228 patients with IF was done, of which 126 were drug-naive (group A) when starting highly active antiretroviral therapy (HAART) and 102 were exposed to mono/dual therapy prior to HAART initiation (group B). A validated in-house genotyping method and Stanford interpretation was used. Means, sd, median and frequencies (as percentages) were used to indicate the patient characteristics in each group. The chi(2) test and Fisher's exact test were used to compare categorical variables as appropriate. All analyses were performed using SPSS software, version 13.0. P-values <0.05 were considered to be statistically significant.
RESULTS: RT drug resistance mutations were found in 92% and 96% of patients in groups A and B, respectively. Median (interquartile range) CD4(+) T-cell count at failure was 181 cells/microl (18-999) and time to failure was 40 months (2-100). M184V (80% versus 75%), thymidine analogue mutations (63% versus 74%), Y181C (39% versus 39%) and K103N (29% versus 39%) were predominant RT mutations in both groups. Extensive nucleoside reverse transcriptase inhibitor cross-resistance mutations were observed in 51% and 26% of patients in group B and A, respectively.
CONCLUSIONS: Alternative strategies for initial therapy and affordable viral load monitoring could reduce resistance accumulations and preserve available drugs for future options in resource-limited settings.
Authors:
Madhavan Vidya; Shanmugam Saravanan; Shanmugasundaram Uma; Nagalingeswaran Kumarasamy; Solomon S Sunil; Rami Kantor; David Katzenstein; Bharat Ramratnam; Kenneth H Mayer; Solomon Suniti; Pachamuthu Balakrishnan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antiviral therapy     Volume:  14     ISSN:  1359-6535     ISO Abbreviation:  Antivir. Ther. (Lond.)     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-02-03     Revised Date:  2013-12-24    
Medline Journal Info:
Nlm Unique ID:  9815705     Medline TA:  Antivir Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1005-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Drug Resistance, Viral / genetics*
Female
Genetic Variation*
HIV Infections / drug therapy*,  epidemiology,  virology
HIV-1 / drug effects,  genetics*
Humans
India / epidemiology
Male
Mutation
Prevalence
RNA, Viral / analysis,  genetics
Reverse Transcriptase Inhibitors / administration & dosage*
Treatment Failure
Grant Support
ID/Acronym/Agency:
D43 TW000237/TW/FIC NIH HHS; R01 AI058736/AI/NIAID NIH HHS; R01 AI066922/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Viral; 0/Reverse Transcriptase Inhibitors
Comments/Corrections

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