Document Detail

Genotypes and virus load in patients with hepatitis C infection.
MedLine Citation:
PMID:  7499000     Owner:  NLM     Status:  MEDLINE    
Virus load was tested by means of PCR calibrated with standards and HCV genotypes were determined by the LIPA-technique using sera from 123 HCV patients. Of these 39 were on renal hemodialysis treatment, 19 suffered from hemophilia, 13 were i.v. drug users and the remaining 52 had none of these risk factors (chronic hepatitis group). The most prevalent subtype in Austria was 1b followed by 3a and 1a. However, genotype 1b infections were found relatively less often in hemophilia patients and drug users than in the other groups, indicating that hemophiliacs probably had been infected by an antihemophilic plasma coming from South American or Asian donors. The highest amounts of virus were found in patients infected with genotype 3a. Determination of the patient's virus load and of the infecting subtype of HCV may be helpful in planning interferon alpha therapy.
H Hofmann
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection     Volume:  23     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Allgemeines Krankenhaus der Stadt Wien, Abt. für Klinische Virologie, Austria.
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MeSH Terms
Chronic Disease
DNA, Viral / analysis
Hemophilia A / complications
Hepacivirus / classification,  genetics*,  isolation & purification
Hepatitis C / etiology,  virology*
Kidney Failure, Chronic / complications
Polymerase Chain Reaction / methods
RNA, Viral / blood,  isolation & purification
Renal Dialysis
Risk Factors
Substance Abuse, Intravenous / complications
Viremia / virology*
Reg. No./Substance:
0/DNA, Viral; 0/RNA, Viral

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