Document Detail


Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients.
MedLine Citation:
PMID:  16697726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Genotypes and viremia of hepatitis D virus (HDV) and hepatitis B virus (HBV) may be associated with outcomes. This study evaluated the impact of viral genotypes and viremia on outcomes of dual HBV and HDV infection. METHODS: Viremia and viral genotypes were analyzed in 194 consecutive chronic hepatitis B patients with HDV superinfection and correlated with outcomes. RESULTS: The numbers of HBV genotype A, B, C, and nonclassified were 4, 57, 23, and 110, respectively. There were 51 genotype I HDV, 74 genotype II HDV, 8 genotype IV HDV, and 61 nonclassified HDV genotype. In a median follow-up of 135 months, 24 progressed to cirrhosis and 41 developed hepatocellular carcinoma. Patients infected with genotype I HDV had a lower remission rate (15.2% vs 40.2%; P = .007) and more adverse outcomes (cirrhosis, hepatocellular carcinoma, or mortality) (52.2% vs 25.0%; P= .005) than those with genotype II HDV. Patients infected with genotype C HBV had a lower remission rate (0 vs 32.1%; P = .005) and more adverse outcomes (70.0% vs 33.9%; P = .005) than those with genotype B HBV. The presence of HBV or HDV viremia was associated with lower remission rates compared with those negative for both (26.4% and 24.3% vs 69.2%; P < .001). In multivariate analysis, age, genotype C HBV, and genotype I HDV were independent factors associated with adverse outcomes. CONCLUSIONS: In chronic HBV and HDV dual infections, older age, genotype I HDV, and genotype C HBV correlated with adverse outcomes.
Authors:
Chien-Wei Su; Yi-Hsiang Huang; Teh-Ia Huo; Hsuan Hui Shih; I-Jane Sheen; Su-Wen Chen; Pui-Ching Lee; Shou-Dong Lee; Jaw-Ching Wu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  130     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1625-35     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Cohort Studies
DNA, Viral / genetics*
Disease Progression
Female
Gene Expression Regulation
Genetic Markers
Genetic Predisposition to Disease*
Genotype
Hepatitis B, Chronic / epidemiology,  genetics*,  physiopathology
Hepatitis D, Chronic / epidemiology,  genetics*,  physiopathology
Humans
Incidence
Liver Function Tests
Male
Middle Aged
Multivariate Analysis
Probability
Prognosis
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Survival Rate
Taiwan / epidemiology
Viremia / epidemiology,  genetics*,  physiopathology
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Genetic Markers

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