Document Detail

Genotype of stearoyl-coA desaturase is associated with fatty acid composition in Japanese Black cattle.
MedLine Citation:
PMID:  15058385     Owner:  NLM     Status:  MEDLINE    
To investigate the genetic factors that affect fatty acid composition of beef, we compared the full-length bovine stearoyl-CoA desaturase (SCD) cDNA from 20 Japanese Black steers. Two types of the SCD gene with single nucleotide polymorphisms (SNPs) were observed in the ORF of SCD cDNA, in which an amino acid replacement from valine (type V) to alanine (type A) was predicted. We developed a method for genotyping these two SCD genes based on PCR-RFLP. We have classified 1003 Japanese Black carcasses into three genotypes, VV, VA, and AA, and compared fatty acid composition among them. The SCD type A gene contributed to higher MUFA percentage and lower melting point in intramuscular fat. The SCD genotype was not the only genetic factor contributing to fatty acid composition of Japanese Black steers, but the SCD genotype was considered one of the causes of genetic variation in fatty acid composition of Japanese Black steers. Transcription factors such as sterol regulatory element binding protein-1c (SREBP-1c) may account for the remaining part of the genetic variation in fatty acid composition.
Masaaki Taniguchi; Takeshi Utsugi; Kenji Oyama; Hideyuki Mannen; Masato Kobayashi; Yoshihiro Tanabe; Atsushi Ogino; Soichi Tsuji
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  15     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-05-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Laboratory of Animal Breeding & Genetics, Graduate School of Science and Technology, Kobe University, Nada-ku, Kobe 657-8501, Japan.
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MeSH Terms
Amino Acid Sequence
Analysis of Variance
Base Sequence
Body Composition*
Cattle / genetics*
DNA Primers
DNA, Complementary / genetics
Fatty Acids / analysis,  genetics*
Molecular Sequence Data
Polymorphism, Restriction Fragment Length
Sequence Analysis, DNA
Stearoyl-CoA Desaturase / genetics*
Reg. No./Substance:
0/DNA Primers; 0/DNA, Complementary; 0/Fatty Acids; EC Desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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