Document Detail

Genotype-specific reduction in methyl nitrosourea (MNU) induced sister chromatid exchanges (SCE) in vivo during aging.
MedLine Citation:
PMID:  3416998     Owner:  NLM     Status:  MEDLINE    
We studied mice from five strains (BALB/c, C3H/HeSnJ, C57BL/6J, Csb and 129/ReJ) at two ages (young, 10 +/- 1 weeks; and old, 67 +/- 3 weeks) for the induction of sister chromatid exchanges (SCEs) in vivo by methyl nitrosourea (MNU). The SCE frequency is genotype-specific. The F1 phenotype resembles the 'low' responding parent. SCE induction is significantly lower in the older animals of each strain than their younger counterparts, and the reduction of SCE/cell with old age is strain-specific. A general explanation for these results must include strain differences in relative mutagenic sensitivity, genotype-specific pattern of reduction in DNA repair and other such factors affecting SCE formation, with old age.
S L Bond; S M Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  44     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-27     Completed Date:  1988-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  782-5     Citation Subset:  IM    
Department of Zoology, Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
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MeSH Terms
Body Weight
DNA Damage
DNA Repair
Dose-Response Relationship, Drug
Methylnitrosourea / pharmacology*
Mice, Inbred Strains / genetics*
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:

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