| Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke. | |
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MedLine Citation:
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PMID: 20193673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gamma-glutamyl carboxylation, a reaction essential for the biosynthesis of vitamin K-dependent coagulation factors, requires the participation of the gamma-glutamyl carboxylase (GGCX), vitamin K epoxide reductase (VKORC1), and NAD(P)H:quinone oxidoreductase (NQO1). We evaluated the role of these genotype polymorphisms in patients with large-artery atherosclerotic stroke. METHODS: In this hospital-based case-control study, 117 patients who were categorized as having large-artery atherosclerotic stroke and 115 age- and gender-matched controls were recruited. Genotyping determination for the GGCX1 (Gln325Arg), NQO1 (Pro187Ser), and VKORC1 (rs9923231) polymorphisms was performed. The associations of genotype with ischemic stroke (IS) risk were examined. RESULTS: A higher genotypic frequency of NQO1 C609T was found in the controls than in the patients, manifesting a 0.47-fold risk reduction in IS (95% CI=0.25-0.87). A tendency toward a reduced IS risk was statistically significant in those subjects who carried a greater number of the NQO1, GGCX, and VKORC1 polymorphisms (aOR=0.58, P(trend)=0.005). The synergistic effect of multiple genes on risk reduction was more significant in a subset of patients who were not alcoholics and who were non-smokers (P<0.05). CONCLUSIONS: Compartmentation of coagulation factor metabolism may account for the preferential role of NQO1, GGCX, and VKORC1 polymorphisms to lower the risk for large-artery atherosclerotic stroke. |
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Authors:
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Hann-Yeh Shyu; Chin-Shih Fong; Yi-Ping Fu; Jia-Ching Shieh; Jiu-Haw Yin; Ching-Yi Chang; Hsiao-Wei Wang; Chun-Wen Cheng |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-03-01 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-11-29 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 840-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Neurology Section, Internal Medicine Department, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Atherosclerosis / enzymology, genetics* Carbon-Carbon Ligases / genetics* Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Middle Cerebral Artery / enzymology, pathology Mixed Function Oxygenases / genetics* NAD(P)H Dehydrogenase (Quinone) / genetics* Polymorphism, Genetic / genetics* Risk Factors Stroke / enzymology, genetics*, pathology |
| Chemical | |
Reg. No./Substance:
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EC 1.-/Mixed Function Oxygenases; EC 1.14.99.-/vitamin K epoxidase; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human; EC 6.4.-/Carbon-Carbon Ligases; EC 6.4.-/glutamyl carboxylase |
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