Document Detail

Genotype and plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events.
MedLine Citation:
PMID:  15860739     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Cysteine proteases and their inhibitors such as cystatin C are assumed to play an important role in the pathogenesis of atherosclerosis and coronary heart disease (CHD). The aim of the study was to investigate the impact of cystatin C polymorphisms on cystatin C plasma levels and on prognosis of patients with CHD. METHODS AND RESULTS: Four polymorphisms in the promoter and exon 1 of the cystatin C gene (-82GC, -5GA, +4AC, and +148AG) and cystatin C plasma levels were determined in a cohort of 1013 patients with manifest CHD and aged 30 to 70 years participating in an in-hospital rehabilitation program. Patients were followed-up for a mean of 33.5 months and a combined end point (fatal and nonfatal cardiovascular disease [CVD] events) was used as the outcome variable. The major haplotype -82G/-5G/+4A was associated with cystatin C plasma levels with persons homozygous for the major haplotype having the highest levels (P=0.01). However, the haplotype was not associated with fatal and nonfatal cardiovascular events during the 3-year follow-up. CONCLUSIONS: The major haplotype -82G/-5G/+4A of the cystatin C gene determines plasma levels of cystatin C with homozygous persons having the highest plasma levels, but there was no association with secondary CVD events in this study.
Michael Loew; Michael M Hoffmann; Wolfgang Koenig; Hermann Brenner; Dietrich Rothenbacher
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Publication Detail:
Type:  Journal Article     Date:  2005-04-28
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  25     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1470-4     Citation Subset:  IM    
Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany.
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MeSH Terms
Cohort Studies
Coronary Disease / blood,  epidemiology*,  genetics*
Cystatin C
Cystatins / blood*,  genetics*
Exons / genetics
Follow-Up Studies
Genetic Predisposition to Disease / epidemiology
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic / genetics
Prospective Studies
Risk Factors
Reg. No./Substance:
0/CST3 protein, human; 0/Cystatin C; 0/Cystatins

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