Document Detail


Genotype, phenotype and cancer: role of low penetrance genes and environment in tumour susceptibility.
MedLine Citation:
PMID:  15824445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.
Authors:
Ashwin Kotnis; Rajiv Sarin; Rita Mulherkar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biosciences     Volume:  30     ISSN:  0250-5991     ISO Abbreviation:  J. Biosci.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-09-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8100809     Medline TA:  J Biosci     Country:  India    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
Affiliation:
Genetic Engineering, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India.
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MeSH Terms
Descriptor/Qualifier:
Environment*
Epigenesis, Genetic
Genetic Determinism
Genetic Predisposition to Disease*
Genotype
Humans
Life Style
Neoplasms / etiology*,  genetics*
Penetrance*
Phenotype
Polymorphism, Single Nucleotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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