| Genotype-phenotype associations between chymase and angiotensin-converting enzyme gene polymorphisms in chronic systolic heart failure patients. | |
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MedLine Citation:
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PMID: 18641516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Angiotensin II, which plays a crucial role in the myocardial remodeling process of heart failure, is generated via the angiotensin-converting enzyme and chymase pathways. We studied angiotensin-converting enzyme and chymase-1 polymorphisms in patients with systolic heart failure and the correlation with clinical status and left ventricular function. METHODS: We genotyped 195 patients with heart failure and systolic left ventricular dysfunction (ejection fraction <40%) for angiotensin-converting enzyme insertion (I)/deletion (D) and chymase-1 (-1903G/A) polymorphisms. Heart failure etiology and patients' clinical manifestations were analyzed in relation to genotype subtypes. RESULTS: The chymase-1 -1903 GG genotype was associated with a nonischemic heart failure etiology (chi = 6.67, P = 0.009). In the group of heart failure patients, the odds ratio of chymase-1 GG genotype having a nonischemic etiology was 2.48 (95% CI 1.23-5.00). The chymase-1 GG genotype was associated with lower ejection fraction (P = 0.005). Conversely, the angiotensin-converting enzyme D allele had no detectable impact on systolic heart failure phenotype. CONCLUSIONS: In patients with chronic systolic heart failure, the chymase-1 polymorphism was related to nonischemic etiology of heart failure. Patients homozygous for the G allele had a significantly greater reduction in systolic left ventricular function. |
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Authors:
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Ruthie E Amir; Offer Amir; Hagar Paz; Moran Sagiv; Roi Mor; Michael Sagiv; Basil S Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genetics in medicine : official journal of the American College of Medical Genetics Volume: 10 ISSN: 1530-0366 ISO Abbreviation: Genet. Med. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2009-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815831 Medline TA: Genet Med Country: United States |
Other Details:
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Languages: eng Pagination: 593-8 Citation Subset: IM |
Affiliation:
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Department of Genetics and Molecular Biology, Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, Israel. ruthiea@wincol.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Chymases / genetics* Female Genotype Heart Failure, Systolic / genetics* Humans Male Middle Aged Peptidyl-Dipeptidase A / genetics* Phenotype* Polymorphism, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.21.39/Chymases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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