Document Detail

Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study.
MedLine Citation:
PMID:  16468038     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: It has been suggested that the gene encoding lymphotoxin-alpha (LTA) is associated with insulin resistance, and genetic association studies in the LTA region offer some support for this. However, LTA is in linkage disequilibrium with both the HLA gene cluster and the gene encoding TNF-alpha, making inferences about causality difficult. In this study, we used the galectin 2 (LGALS2) genotype, which affects LTA secretion but is located on another chromosome than the HLA gene cluster or TNF, to examine the relationship between the LTA pathway and traits of the metabolic syndrome. SUBJECTS: A cross-sectional genetic association study was carried out in 3,272 British women of European origin who were aged 60 to 79 years and were randomly selected from the community. RESULTS: Fasting plasma glucose and serum insulin were statistically significantly associated with LGALS2 rs7291467, with this association being independent of BMI and WHR. The mean difference in fasting insulin per minor allele was -4% (p=0.01 for trend by allele) and the mean per minor allele difference in fasting glucose was -2% (p=0.02 for trend by allele). When women with known diabetes were excluded from the analyses the findings did not differ from those for the whole cohort. CONCLUSIONS/INTERPRETATION: Our findings for the physically unlinked LGALS2, invite further study of LGALS2 specifically and the LTA pathway generally for their influence on glucose-insulin regulation.
M B Christensen; D A Lawlor; T R Gaunt; W M Howell; M W Howell; G Davey Smith; S Ebrahim; I N M Day
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-09
Journal Detail:
Title:  Diabetologia     Volume:  49     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-09     Completed Date:  2006-10-17     Revised Date:  2007-02-06    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  673-7     Citation Subset:  IM    
Human Genetics Division School of Medicine, Southampton University Hospital, Southampton SO16 6YD, UK.
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MeSH Terms
Blood Glucose / metabolism*
Galectin 2 / genetics*
Great Britain
Health Surveys*
Insulin / blood*
Life Style
Middle Aged
Reg. No./Substance:
0/Blood Glucose; 0/Galectin 2; 11061-68-0/Insulin
Erratum In:
Diabetologia. 2006 Nov;49(11):2815
Note: Howell, M W [corrected to Howell, W M]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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