Document Detail


Genotype-based changes in serum uric acid affect blood pressure.
MedLine Citation:
PMID:  22189840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymorphism, rs16890979 (Val253Ile), in the SLC2A9 gene. This gene expresses the GLUT9 transporter that also transports uric acid and is associated with lower serum uric acid levels. We studied the unconfounded association between genotype and blood pressure in 516 Amish adults, each placed for 6 days on standardized diets, first with high sodium, followed by low sodium, with an intervening washout period. Blood pressure, measured using 24-h ambulatory monitoring, during both diet periods was used as the primary outcome. All participants were free of diuretic or other antihypertensive medications and the relationships between GLUT9 genotype and both serum uric acid and blood pressure were assessed. Each copy of the GLUT9 minor Ile allele was found to confer a significant 0.44 mg/dl reduction in serum uric acid and was associated with a significant mean decrease in the systolic blood pressure of 2.2 and 1.5 mm Hg on the high- and low-sodium diet, respectively. Thus, a Mendelian randomization analysis using variants in the GLUT9 gene indicates that a decrease in serum uric acid has a causal effect of lowering blood pressure.
Authors:
Afshin Parsa; Eric Brown; Matthew R Weir; Jeffrey C Fink; Alan R Shuldiner; Braxton D Mitchell; Patrick F McArdle
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-21
Journal Detail:
Title:  Kidney international     Volume:  81     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-15     Completed Date:  2012-06-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-7     Citation Subset:  IM    
Affiliation:
Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. aparsa@medicine.maryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Amish / genetics
Blood Pressure / drug effects,  genetics*,  physiology
Diet, Sodium-Restricted
Female
Genotype*
Glucose Transport Proteins, Facilitative / genetics*
Humans
Hypertension / diet therapy,  genetics*,  physiopathology
Male
Middle Aged
Pennsylvania
Polymorphism, Single Nucleotide / genetics*
Retrospective Studies
Sodium Chloride, Dietary / pharmacology
Uric Acid / blood*
Grant Support
ID/Acronym/Agency:
K12 RR023250/RR/NCRR NIH HHS; K12RR023250/RR/NCRR NIH HHS; M01 RR 16500/RR/NCRR NIH HHS; M01 RR016500/RR/NCRR NIH HHS; P30 DK072488/DK/NIDDK NIH HHS; P30 DK072488/DK/NIDDK NIH HHS; U01 HL072515/HL/NHLBI NIH HHS; U01 HL72515/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucose Transport Proteins, Facilitative; 0/SLC2A9 protein, human; 0/Sodium Chloride, Dietary; 69-93-2/Uric Acid
Comments/Corrections
Comment In:
Kidney Int. 2012 Aug;82(3):360; author reply 360-1   [PMID:  22791323 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optimization of alternating TR-SSFP for fat-suppression in abdominal images at 3T.
Next Document:  The impact of renin-angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients...