Document Detail


Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings.
MedLine Citation:
PMID:  12195356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the influence of Toxoplasma gondii genotypes on the severity of human congenital toxoplasmosis (asymptomatic, benign, or severe infection or newborn or fetal death), 8 microsatellite markers were used to analyze 86 T. gondii isolates collected from patients with congenital toxoplasmosis. Seventy-four different genotypes were detected, some identical genotypes originating probably from the same source of contamination. The 3 less polymorphic microsatellite markers associated with 6 isoenzymatic markers allowed a classification of isolates into the 3 classical types and detected atypical genotypes. Whatever the clinical findings, type II isolates were largely predominant (84.88% in the whole collection and 96.49% in 57 consecutive cases). Type I and atypical isolates were not found in asymptomatic or benign congenital toxoplasmosis. However, in 4 cases in which children were not infected despite isolation of T. gondii from placenta, only type I isolates were found.
Authors:
Daniel Ajzenberg; Nadine Cogné; Luc Paris; Marie-Hélène Bessières; Philippe Thulliez; Denis Filisetti; Hervé Pelloux; Pierre Marty; Marie-Laure Dardé
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Publication Detail:
Type:  Journal Article     Date:  2002-08-05
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  186     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-26     Completed Date:  2002-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  684-9     Citation Subset:  AIM; IM    
Affiliation:
Service de Parasitologie-Mycologie, EA 3174, Faculté de Médecine, Limoges, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cluster Analysis
DNA, Bacterial / chemistry,  genetics
Female
Fetal Death / genetics,  microbiology,  pathology
Humans
Infant, Newborn
Microsatellite Repeats / genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Pregnancy
Toxoplasma / classification,  genetics*
Toxoplasmosis, Congenital / microbiology*,  pathology
Chemical
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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