| Genotoxicity study of reaction products of sorbic acid. | |
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MedLine Citation:
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PMID: 10956157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sorbic acid (E200) and its salts (potassium and calcium sorbate: E202 and E203) are allowed for use as preservatives in numerous processed foods. Sorbic acid has a conjugated system of double bonds which makes it susceptible to nucleophilic attack, sometimes giving mutagenic products. Under conditions typical of food processing (50-80 degrees C), we analyzed the cyclic derivatives resulting from a double addition reaction between sorbic acid and various amines. Mutagenesis studies, involving the Ames test and genotoxicity studies with HeLa cells and plasmid DNA, showed that none of the products studied presented either mutagenic or genotoxic activities. |
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Authors:
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C Ferrand; F Marc; P Fritsch; P Cassand; G de Saint Blanquat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 48 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-25 Completed Date: 2000-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3605-10 Citation Subset: IM |
Affiliation:
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Laboratoire d'Analyse de la Valeur Biologique des Aliments, Département Universitaire des Sciences d'Agen, Université Bordeaux I, France. dusa@dus-agen.u-bordeaux.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Mutagenicity Tests Salmonella typhimurium / genetics Sorbic Acid / chemistry*, toxicity* |
| Chemical | |
Reg. No./Substance:
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110-44-1/Sorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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