Document Detail


Genotoxicity study of reaction products of sorbic acid.
MedLine Citation:
PMID:  10956157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sorbic acid (E200) and its salts (potassium and calcium sorbate: E202 and E203) are allowed for use as preservatives in numerous processed foods. Sorbic acid has a conjugated system of double bonds which makes it susceptible to nucleophilic attack, sometimes giving mutagenic products. Under conditions typical of food processing (50-80 degrees C), we analyzed the cyclic derivatives resulting from a double addition reaction between sorbic acid and various amines. Mutagenesis studies, involving the Ames test and genotoxicity studies with HeLa cells and plasmid DNA, showed that none of the products studied presented either mutagenic or genotoxic activities.
Authors:
C Ferrand; F Marc; P Fritsch; P Cassand; G de Saint Blanquat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  48     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-25     Completed Date:  2000-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3605-10     Citation Subset:  IM    
Affiliation:
Laboratoire d'Analyse de la Valeur Biologique des Aliments, Département Universitaire des Sciences d'Agen, Université Bordeaux I, France. dusa@dus-agen.u-bordeaux.fr
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MeSH Terms
Descriptor/Qualifier:
Mutagenicity Tests
Salmonella typhimurium / genetics
Sorbic Acid / chemistry*,  toxicity*
Chemical
Reg. No./Substance:
110-44-1/Sorbic Acid

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