Document Detail

Genotoxicity studies of organically grown broccoli (Brassica oleracea var. italica) and its interactions with urethane, methyl methanesulfonate and 4-nitroquinoline-1-oxide genotoxicity in the wing spot test of Drosophila melanogaster.
MedLine Citation:
PMID:  19786056     Owner:  NLM     Status:  MEDLINE    
Broccoli (Brassica oleracea var. italica) has been defined as a cancer preventive food. Nevertheless, broccoli contains potentially genotoxic compounds as well. We performed the wing spot test of Drosophila melanogaster in treatments with organically grown broccoli (OGB) and co-treatments with the promutagen urethane (URE), the direct alkylating agent methyl methanesulfonate (MMS) and the carcinogen 4-nitroquinoline-1-oxide (4-NQO) in the standard (ST) and high bioactivation (HB) crosses with inducible and high levels of cytochrome P450s (CYPs), respectively. Larvae of both crosses were chronically fed with OGB or fresh market broccoli (FMB) as a non-organically grown control, added with solvents or mutagens solutions. In both crosses, the OGB added with Tween-ethanol yielded the expected reduction in the genotoxicity spontaneous rate. OGB co-treatments did not affect the URE effect, MMS showed synergy and 4-NQO damage was modulated in both crosses. In contrast, FMB controls produced damage increase; co-treatments modulated URE genotoxicity, diminished MMS damage, and did not change the 4-NQO damage. The high dietary consumption of both types of broccoli and its protective effects in D. melanogaster are discussed.
Mar?a Eugenia Heres-Pulido; Irma Due?as-Garc?a; Laura Casta?eda-Partida; Luis Felipe Santos-Cruz; Viridiana Vega-Contreras; Rosa Rebollar-Vega; Juan Carlos G?mez-Luna; Angel Dur?n-D?az
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Publication Detail:
Type:  Journal Article     Date:  2009-09-26
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Genetic Toxicology, Biology, FES Iztacala, Universidad Nacional Aut?noma de M?xico, 54090 Tlalnepantla, Estado de M?xico, Mexico.
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MeSH Terms
4-Nitroquinoline-1-oxide / toxicity
Brassica / toxicity*
Cytochromes / metabolism
DNA / drug effects,  genetics
DNA Adducts / drug effects
Drosophila melanogaster
Free Radical Scavengers / chemistry
Freeze Drying
Health Food / analysis,  toxicity*
Methyl Methanesulfonate / toxicity*
Mutagenicity Tests
Mutagens / toxicity*
Purines / chemistry
Quinolones / toxicity*
Reactive Oxygen Species / chemistry
Ultraviolet Rays
Urethane / chemistry,  toxicity*
Wing / physiology*
Reg. No./Substance:
0/4-nitroquinolone-1-oxide; 0/Cytochromes; 0/DNA Adducts; 0/Free Radical Scavengers; 0/Mutagens; 0/Purines; 0/Quinolones; 0/Reactive Oxygen Species; 120-73-0/purine; 51-79-6/Urethane; 56-57-5/4-Nitroquinoline-1-oxide; 66-27-3/Methyl Methanesulfonate; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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