Document Detail

Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes.
MedLine Citation:
PMID:  10613189     Owner:  NLM     Status:  MEDLINE    
Ochratoxin A (OTA) was, up to now, believed to be non-mutagenic in the classical Salmonella typhimurium reverse mutation test. This was confirmed using rat liver microsomal fractions with the strains, TA1535, TA1538 and TA98, and up to 1210 micrograms/plate, utilizing an Ames microtest. However, using mice kidney microsomal fractions as metabolic activators, reverse mutations were obtained with the three strains used, in the presence of either NADP or arachidonic acid as cofactors. The mutagenicity was higher with arachidonic acid than with NADP using the TA1535 strain. This lends support to the results concerning the DNA or dGMP adducts obtained in vitro which were also higher in the presence of arachidonic acid, and indicate that several metabolic pathways of OTA can lead to genotoxic compounds. In addition, both base pair substitutions and frameshift mutations can be caused by OTA after metabolic activation.
S Obrecht-Pflumio; T Chassat; G Dirheimer; D Marzin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  446     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-12     Completed Date:  2000-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Laboratoire de Biologie Végétale Appliquée, IUT Louis Pasteur, Schiltigheim, France.
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MeSH Terms
Arachidonic Acid / toxicity
Carcinogens / metabolism,  toxicity*
Dose-Response Relationship, Drug
Kidney / metabolism*
Microsomes / metabolism*
Microsomes, Liver / metabolism
Mutagenicity Tests / methods
Mycotoxins / metabolism,  toxicity*
NADP / pharmacology
Ochratoxins / metabolism,  toxicity*
Rats, Sprague-Dawley
Salmonella typhimurium / drug effects*,  genetics*
Species Specificity
Reg. No./Substance:
0/Carcinogens; 0/Mycotoxins; 0/Ochratoxins; 303-47-9/ochratoxin A; 506-32-1/Arachidonic Acid; 53-59-8/NADP

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