Document Detail


Genotoxicity of nimesulide in murine bone marrow cells.
MedLine Citation:
PMID:  14598607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genotoxic potentiality of nimesulide was evaluated in vivo in murine bone marrow cells. The human equivalent prophylactic dose of nimesulide (5 mg/kg body wt/day) was given to animals orally, once daily for seven consecutive days. Metaphase chromosome analyses revealed the significant increase in the incidence of chromosomal aberrations with preference to structural over the numerical ones. It therefore suggested the clastogenic effect of the nimesulide. The molecular mechanism of mutagenesis is yet to be determined.
Authors:
P K Khan; K Amod; M Haque; A Nath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  17     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  439-40     Citation Subset:  IM    
Affiliation:
Department of Zoology, Patna Women's College, Patna 800 001, India. Parimal_khan@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  toxicity*
Bone Marrow Cells / drug effects*
Chromosome Aberrations / drug effects*
Cytogenetic Analysis
Female
Male
Metaphase
Mice
Mutagenicity Tests
Mutagens / administration & dosage,  toxicity*
Sulfonamides / administration & dosage,  toxicity*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Mutagens; 0/Sulfonamides; 51803-78-2/nimesulide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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