Document Detail


Genotoxicity induced by furocoumarin hydroperoxides in mammalian cells upon UVA irradiation.
MedLine Citation:
PMID:  7488166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mutagenicity and micronucleus induction by the furocoumarin hydroperoxides 1a and 2a and, for comparison, their corresponding alcohols 1b and 2b were investigated in L5178Y tk+/- mouse lymphoma cells and AS52 Chinese hamster ovary cells. The furocoumarin hydroperoxide 1a enhanced the micronucleus frequency in L5178Y tk+/- mouse lymphoma cells significantly, while its alcohol 1b exhibited a rather moderate effect. In contrast, both the furocoumarin hydroperoxide 2a and its alcohol 2b induced high frequencies of micronuclei. Only the furocoumarin hydroperoxide 1a, but not its alcohol 1b, was mutagenic in both L5178Y tk+/- and AS52 cells. On the other hand, the furocoumarin hydroperoxide 2a and its alcohol 2b were mutagenic. For all furocoumarin derivatives 1a,b and 2a,b no mutagenicity and genotoxicity was observed in the absence of UVA light. The multifunctional furocoumarin hydroperoxides may serve as potential photochemotherapeutic agents.
Authors:
M Möller; H Stopper; M Häring; Y Schleger; B Epe; W Adam; C R Saha-Möller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  216     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  693-701     Citation Subset:  IM    
Affiliation:
Department of Toxicology, University of Würzburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells
Coumarins / pharmacology*
Cricetinae
Dose-Response Relationship, Drug
Leukemia L5178
Lymphoma
Mice
Micronuclei, Chromosome-Defective / drug effects,  radiation effects*
Micronucleus Tests
Mutagens / pharmacology*
Peroxides / pharmacology*
Psoralens*
Radiation-Sensitizing Agents / pharmacology*
Tumor Cells, Cultured
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Coumarins; 0/Mutagens; 0/Peroxides; 0/Psoralens; 0/Radiation-Sensitizing Agents; 135366-51-7/9-((2-hydroperoxy-3-methyl-3-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one; 160858-31-1/4-(3-hydroperoxy-3-methyl-1-butenyl)-9-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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