Document Detail


Genotoxicity assessment of new synthesized acridine derivative--3,6-diamino-10-methyl-9,10-dihydroacridine.
MedLine Citation:
PMID:  10521686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new synthesized acridine derivative, 3,6-diamino-10-methyl-9, 10-dihydroacridine (AcrH), was tested for in vitro reverse mutations with Salmonella TA strains, chromosome aberrations and sister chromatid exchanges (SCE) in human lymphocytes, and for in vivo chromosome aberrations in bone marrow of mice. Using the classic plate incorporation method, mutagenicity of AcrH in bacterial cells (TA97a, TA98, TA100 and TA102) was observed in the experiments performed with, and without, rat liver S9 metabolic activation. The reverse mutation assay showed no difference in mutagenic activity between AcrH and acriflavine (Acr(+)) in the test with TA97. The results of in vitro chromosome aberrations assay revealed potential clastogenicity. The test using macroculture of human lymphocytes induced mainly chromatid gaps. The experiments with human lymphocytes revealed SCE-inducing effect of AcrH and Acr(+). In an in vivo study, AcrH given intraperitoneally to Balb/c mice did not cause any significant increase in the percentage of cells with aberrations compared to the negative control.
Authors:
T Ferenc; E Janik-Spiechowicz; W Bratkowska; D Lopaczyńska; H Strózyński; A Denys; A Mordalska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  444     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  463-70     Citation Subset:  IM    
Affiliation:
Department of Biology and Medical Genetics, Military Medical University, 90-647, Lódź, Poland.
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MeSH Terms
Descriptor/Qualifier:
Acridines / toxicity*
Adult
Animals
Chromosome Aberrations
Humans
Male
Mice
Mice, Inbred BALB C
Mutagens / toxicity*
Mutation
Rats
Rats, Wistar
Salmonella typhimurium / drug effects
Sister Chromatid Exchange
Chemical
Reg. No./Substance:
0/3,6-diamino-10-methyl-9,10-dihydroacridine; 0/Acridines; 0/Mutagens

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