Document Detail

Genotoxic effects of sulfur dioxide in human lymphocytes.
MedLine Citation:
PMID:  22903179     Owner:  NLM     Status:  Publisher    
Sulfur dioxide (SO(2)), which is used as food preservative in apricot sulfurization and several fabricated foods, is a common air pollutant. The aim of this study was to reveal the possible genotoxic effects of SO(2) using in vitro human lymphocytes. The different endpoints of genotoxicity: sister chromatid exchange (SCE), micronuclei (MN) tests and cell growth kinetics such as mitotic index (MI) and replication index (RI) were studied. The cells were treated with 0.1, 0.5 and 1.0 ppm concentrations of SO(2). It was shown that SO(2) caused significant increases in the frequency of SCE and MN in the middle and high dosage groups and also induced mitotic delays and decreased MI and RI. In conclusion, the results have confirmed that SO(2) has potent mutagenicity and it can cause genetic damage leading to a malignancy.
Nihal Uren; Sengul Yuksel; Yunus Onal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  Toxicology and industrial health     Volume:  -     ISSN:  1477-0393     ISO Abbreviation:  Toxicol Ind Health     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medical Biology and Genetics, Inonu University, Malatya, Turkey.
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