| Genotoxic effect of substituted phenoxyacetic acids. | |
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MedLine Citation:
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PMID: 11131037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential toxic and mutagenic action of 2,4-dichlorophenoxyacetic acid has been studied in different test systems, and the obtained results range from increased chromosomal damage to no effect at all. We reexamined the effect of this herbicide by simultaneous using three tests based on yeast, transformed hematopoietic, and mouse bone marrow cells. The results obtained demonstrated that 2,4-dichlorophenoxyacetic acid has cytotoxic and mutagenic effects. The positive response of yeast and transformed hematopoietic cells was verified in kinetics and dose-response experiments. The analysis of metaphase chromosomes indicated a statistically proved induction of breaks, deletions, and exchanges after the intraperitoneal administration of 2,4-dichlorophenoxyacetic acid in mice. The study of phenoxyacetic acid and its differently chlorinated derivatives showed that cytotoxicity and mutagenicity are induced by chlorine atoms at position 2 and/or 4 in the benzene ring. The mutagenic effect was abolished by introduction of a third chlorine atom at position 5. Thus 2,4,5-trichlorophenoxyacetic acid was found to have very weak, if any mutagenic effect; however, the herbicide preserved its toxic effect. |
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Authors:
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P Venkov; M Topashka-Ancheva; M Georgieva; V Alexieva; E Karanov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of toxicology Volume: 74 ISSN: 0340-5761 ISO Abbreviation: Arch. Toxicol. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-22 Completed Date: 2001-03-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: Germany |
Other Details:
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Languages: eng Pagination: 560-6 Citation Subset: IM |
Affiliation:
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Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia. Venkov@obzor.bio21.bas.bg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,4,5-Trichlorophenoxyacetic Acid
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toxicity 2,4-Dichlorophenoxyacetic Acid / chemistry, toxicity Animals Chlorine / chemistry Chromosomes / drug effects, ultrastructure Female Hematopoietic Stem Cells / drug effects Herbicides / toxicity Male Mice Mice, Inbred C57BL Mitotic Index Mutagens / chemistry, toxicity* Pesticides / chemistry, toxicity Phenoxyacetates / chemistry, toxicity* Saccharomyces cerevisiae / drug effects, genetics Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Herbicides; 0/Mutagens; 0/Pesticides; 0/Phenoxyacetates; 7782-50-5/Chlorine; 93-76-5/2,4,5-Trichlorophenoxyacetic Acid; 94-75-7/2,4-Dichlorophenoxyacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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