| Genotoxic biomonitoring of agricultural workers exposed to pesticides in the north of Sinaloa State, Mexico. | |
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MedLine Citation:
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PMID: 19665797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genotoxic damage was evaluated in 70 agricultural workers, 25 women and 45 men, exposed to pesticides in Las Grullas, Ahome, Sinaloa, Mexico, with an average of 7 years of exposure. The effect was detected through the sister chromatid exchanges (SCE) in lymphocytes of peripheral blood and micronuclei (MN) and other nuclear anomalies (NA) in buccal exfoliated cells. Also, the influence on cellular proliferation kinetics (CPK) was studied by means of the replication index (RI) and the cytotoxic effect was examined with the mitotic index (MI). The non-exposed group consisted of 70 other persons, 21 women and 47 men from the city of Los Mochis, Sinaloa, Mexico. Significant differences between the exposed and the non-exposed groups were observed in SCE, CPK, MI, MN and NA. Analysis of variance revealed that age, gender, smoking and alcohol consumption did not have a significant effect on genetic damage. However, there was a correlation between exposure time to pesticides and SCE frequency. These results could have been due to the exposure of workers to pesticides containing different chemical compounds. This study afforded valuable data to estimate the possible risk to health associated with pesticide exposure. |
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Authors:
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Carmen Martínez-Valenzuela; Sandra Gómez-Arroyo; Rafael Villalobos-Pietrini; Stefan Waliszewski; María Elena Calderón-Segura; Rubén Félix-Gastélum; Armando Alvarez-Torres |
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Publication Detail:
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Type: Journal Article Date: 2009-08-08 |
Journal Detail:
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Title: Environment international Volume: 35 ISSN: 1873-6750 ISO Abbreviation: Environ Int Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2009-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7807270 Medline TA: Environ Int Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1155-9 Citation Subset: IM |
Affiliation:
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Departamento de Ciencias Biológicas, Universidad de Occidente, Boulevard Macario Gaxiola y Carretera Internacional, Los Mochis 81223, Sinaloa, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agriculture* Cell Proliferation / drug effects Environmental Monitoring Environmental Pollutants / blood, toxicity* Female Humans Lymphocytes / drug effects Male Mexico Middle Aged Mitotic Index Mutagens / metabolism, toxicity* Occupational Exposure / analysis* Pesticides / blood, toxicity* Sister Chromatid Exchange / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Mutagens; 0/Pesticides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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