Document Detail


Genomics and biological activity of neutrophil gelatinase-associated lipocalin in several clinical settings.
MedLine Citation:
PMID:  23343559     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Recent literature has shown that neutrophil gelatinase-associated lipocalin (NGAL) is one of the most interesting and promising biomarkers in case of acute kidney injury. However, several studies indicated that this protein may be applied beyond the boundaries of renal pathophysiology and may be used in other pathophysiological settings since it is also expressed in neutrophils, and respiratory, bowel and prostate epithelia. In this review, we report NGAL genomics and biology and its possible use in several clinical settings. In particular, we review the genomic organization of the NGAL gene, the lipocalin family structure, the interaction between NGAL and ligands, and the induction and expression of NGAL in different conditions.
Authors:
Grazia Maria Virzì; Anna Clementi; Massimo de Cal; Dinna N Cruz; Claudio Ronco
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Publication Detail:
Type:  Journal Article     Date:  2013-01-22
Journal Detail:
Title:  Blood purification     Volume:  35     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Affiliation:
Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
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