Document Detail

Genomics-based food-borne pathogen testing and diagnostics: possibilities for the U.S. Department of Agriculture's Food Safety and Inspection Service.
MedLine Citation:
PMID:  17567844     Owner:  NLM     Status:  MEDLINE    
The use of genomic technologies at the U.S. Department of Agriculture could enhance inspection, monitoring, and risk assessment capabilities within its Food Safety and Inspection Service (FSIS). Molecular assays capable of detecting hundreds of microbial DNA sequences within a single food sample that identify food-borne pathogens of concern and characterize their traits most relevant to human health risk are of great interest for FSIS. For example, a high-density assay, or combination of assays, could screen FSIS inspected food for pathogens relevant to public health (e.g., Salmonella, Listeria, and toxic E. coli) as well as their associated virulence factors and antibiotic resistance genes. Because most genotype assays can be completed in one working day with a minimum of reagents, use of such assays could potentially save FSIS a significant amount of cost/time for analyses. Further, a genotype assay can detect specific microbial traits relevant to human health risk based on the DNA sequence of toxin producing genes, antibiotic resistance alleles, and more. By combining rapid analysis with specific data on human health risks, information from such high-density genotype assays could provide expanded support for test and hold situations, recalls, outbreak management, and microbial risk assessments (e.g., provide data needed for food-borne illness source attribution). Environ. Mol. Mutagen.
James Withee; Kerry L Dearfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental and molecular mutagenesis     Volume:  48     ISSN:  0893-6692     ISO Abbreviation:  Environ. Mol. Mutagen.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800109     Medline TA:  Environ Mol Mutagen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Office of Public Health Science (OPHS), Food Safety and Inspection Service (FSIS), U.S. Department of Agriculture (USDA), Washington, District of Columbia 20250, USA.
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MeSH Terms
Consumer Product Safety / legislation & jurisprudence,  standards*
Food Inspection / legislation & jurisprudence,  standards*
Food Microbiology / legislation & jurisprudence,  standards*
Genomics / legislation & jurisprudence,  methods*,  standards
Models, Theoretical
United States
United States Department of Agriculture

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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