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Genomic view on the peopling of India.
MedLine Citation:
PMID:  23020857     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
India is known for its vast human diversity, consisting of more than four and a half thousand anthropologically well-defined populations. Each population differs in terms of language, culture, physical features and, most importantly, genetic architecture. The size of populations varies from a few hundred to millions. Based on the social structure, Indians are classified into various caste, tribe and religious groups. These social classifications are very rigid and have remained undisturbed by emerging urbanisation and cultural changes. The variable social customs, strict endogamy marriage practices, long-term isolation and evolutionary forces have added immensely to the diversification of the Indian populations. These factors have also led to these populations acquiring a set of Indian-specific genetic variations responsible for various diseases in India. Interestingly, most of these variations are absent outside the Indian subcontinent. Thus, this review is focused on the peopling of India, the caste system, marriage practice and the resulting health and forensic implications.
Authors:
Rakesh Tamang; Kumarasamy Thangaraj
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Publication Detail:
Type:  Journal Article     Date:  2012-10-01
Journal Detail:
Title:  Investigative genetics     Volume:  3     ISSN:  2041-2223     ISO Abbreviation:  Investig Genet     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-05     Completed Date:  2012-12-06     Revised Date:  2013-02-15    
Medline Journal Info:
Nlm Unique ID:  101546908     Medline TA:  Investig Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  20     Citation Subset:  -    
Affiliation:
CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India. thangs@ccmb.res.in.
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