Document Detail


Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5).
MedLine Citation:
PMID:  8786117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular endothelial cadherin (VE-cadherin) is located strictly at endothelial junctions and appears to be a major adhesive component of cell to cell contacts. Genomic clones spanning 36 kb and encompassing the mouse VE-cadherin gene have been isolated and characterized. The gene is composed of 12 exons that exhibit conventional vertebrate splicing. The first exon is entirely untranslated, and both exons 2 and 12 contain untranslated regions. A single major transcriptional start site was identified and located 75 bases upstream of the translation initiation codon in the cDNA sequence. The proximal 5'-flanking domain lacks consensus TATA and CAAT boxes at the usual positions. Exon-intron boundaries are similar to those of other cadherin genes, with some exceptions that may have a functional significance in VE-cadherin behavior. The VE-cadherin gene (locus Cdh5) maps to mouse chromosome 8, where it colocalizes with E-cadherin (locus Cdh1), P-cadherin (locus Cdh3), and M-cadherin (locus Cdh14) genes, suggesting that it might be part of a larger cluster of cadherin sequences.
Authors:
P Huber; J Dalmon; J Engiles; F Breviario; S Gory; L D Siracusa; A M Buchberg; E Dejana
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Genomics     Volume:  32     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-20     Completed Date:  1996-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-8     Citation Subset:  IM    
Affiliation:
CEA, INSERM unité 217, Département de Biolgie Moléculaire et Structurale, Grenoble, France.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X83677;  X83678
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens, CD
Base Sequence
Cadherins / genetics*
Chromosome Mapping*
Cloning, Molecular
Crosses, Genetic
DNA / genetics
Endothelium, Vascular / metabolism
Exons
Female
Genome*
Introns
Male
Mice
Molecular Sequence Data
Multigene Family
Muridae
Sequence Homology, Amino Acid
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Cadherins; 0/cadherin 5; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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