Document Detail


Genomic stability disorders: from budding yeast to humans .
MedLine Citation:
PMID:  23277058     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human genetic disorders with increased genome instability and cancer predisposition have benefited greatly from studies in budding yeast. Here, we present some of the examples where yeast research into DNA damage responses and telomere maintenance pathways paved the way to understanding these processes, and their involvement in selected human diseases.
Authors:
Nicolas C Hoch; Xianning Lai; Jorg Heierhorst
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-411     Citation Subset:  IM    
Affiliation:
St. Vincent's Institute, 9 Princes Street, Fitzroy, VIC, 3065 Australia.
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