| Genomic signatures of diet-related shifts during human origins. | |
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MedLine Citation:
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PMID: 21177690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are numerous anthropological analyses concerning the importance of diet during human evolution. Diet is thought to have had a profound influence on the human phenotype, and dietary differences have been hypothesized to contribute to the dramatic morphological changes seen in modern humans as compared with non-human primates. Here, we attempt to integrate the results of new genomic studies within this well-developed anthropological context. We then review the current evidence for adaptation related to diet, both at the level of sequence changes and gene expression. Finally, we propose some ways in which new technologies can help identify specific genomic adaptations that have resulted in metabolic and morphological differences between humans and non-human primates. |
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Authors:
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Courtney C Babbitt; Lisa R Warner; Olivier Fedrigo; Christine E Wall; Gregory A Wray |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-12-22 |
Journal Detail:
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Title: Proceedings. Biological sciences / The Royal Society Volume: 278 ISSN: 1471-2954 ISO Abbreviation: Proc. Biol. Sci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-06-09 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101245157 Medline TA: Proc Biol Sci Country: England |
Other Details:
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Languages: eng Pagination: 961-9 Citation Subset: IM |
Affiliation:
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Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. courtney.babbitt@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Base Sequence Biological Evolution* Diet Gene Expression Genomics Hominidae / anatomy & histology, genetics*, metabolism*, physiology Humans Primates / genetics, metabolism, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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