Document Detail


Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).
MedLine Citation:
PMID:  1386338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genomic sequence of human interleukin-11 (IL11) has been isolated based on its sequence homology with a cDNA clone encoding primate IL11. The human IL11 genomic sequence is 7 kb in length and consists of five exons and four introns. The IL11 gene has been localized to the long arm of human chromosome 19 at band 19q13.3-q13.4 by in situ hybridization. Several potential transcriptional control sequences that may play an important role in the control of IL11 gene expression have been identified within the 5'-flanking region of the human IL11 gene. The 5'-flanking region of the human IL11 gene contains sequences similar to those present in the 5'-regulatory regions of other cytokine genes. Four repeats of a 30-bp DNA segment were found in the fourth intron, and several copies of ATTTA and Alu repetitive sequences were identified in the 3'-noncoding region of the human IL11 gene. A DNA sequence (ACATGGCAAAACCC) that has 71% similarity with the IL1-responsive element of the IL6 gene was found in the 3'-flanking region of the human IL11 gene. The two polyadenylation sites located at nucleotide positions 6762 and 5591 correspond to the 2.5- and 1.5-kb IL11 transcripts expressed in IL1-induced PU-34 cells. The availability of the human IL11 genomic sequence should aid in studies of the regulatory mechanisms of IL11 gene expression in different cell types and the role of IL11 expression in the hematopoietic microenvironment.
Authors:
D McKinley; Q Wu; T Yang-Feng; Y C Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  814-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M81890;  M84017;  M84534;  M84535;  M84536;  M84537;  M84538;  M84539;  M84543;  M84544
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Cytokines / genetics
DNA / genetics
Exons
Genes, Regulator
Humans
Interleukin-11
Interleukins / genetics*
Introns
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-11; 0/Interleukins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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