| Genomic risk of hepatitis C-related hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 21963516 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P <1 10(⁻5)) in the genome-wide association study were further genotyped in 673 cases and 2596 controls. We found a previously unidentified locus in the 50 flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 10(⁻13), odds ratio = 1.39) to be strongly associated with HCV induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 10(⁻8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 10(⁻13)). |
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Authors:
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Yujin Hoshida; Bryan C Fuchs; Kenneth K Tanabe |
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Publication Detail:
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Type: Comment; Journal Article Date: 2011-09-29 |
Journal Detail:
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Title: Journal of hepatology Volume: 56 ISSN: 1600-0641 ISO Abbreviation: J. Hepatol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-06-12 Revised Date: 2012-08-24 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 729-30 Citation Subset: - |
Affiliation:
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Cancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. hoshida@broadinstitute.org |
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| Comments/Corrections | |
Comment On:
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Nat Genet. 2011 May;43(5):455-8
[PMID:
21499248
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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