Document Detail


Genomic risk of hepatitis C-related hepatocellular carcinoma.
MedLine Citation:
PMID:  21963516     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P <1 10(⁻5)) in the genome-wide association study were further genotyped in 673 cases and 2596 controls. We found a previously unidentified locus in the 50 flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 10(⁻13), odds ratio = 1.39) to be strongly associated with HCV induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 10(⁻8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 10(⁻13)).
Authors:
Yujin Hoshida; Bryan C Fuchs; Kenneth K Tanabe
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Publication Detail:
Type:  Comment; Journal Article     Date:  2011-09-29
Journal Detail:
Title:  Journal of hepatology     Volume:  56     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-12     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  729-30     Citation Subset:  -    
Affiliation:
Cancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. hoshida@broadinstitute.org
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Comment On:
Nat Genet. 2011 May;43(5):455-8   [PMID:  21499248 ]

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