| Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. | |
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MedLine Citation:
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PMID: 9192849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitogen-activated protein kinase phosphatases (MKPs) play a central role in a variety of signaling pathways. We recently described a novel murine MKP, M3/6, which is uniquely specific for c-Jun N-terminal kinase/stress-activated protein kinase and p38 kinase. Here we report the localization of the human orthologue of this gene, HB5, to within 150 kb of H19 on human chromosome 11p15.5. The gene consists of six exons. Two of the introns in HB5 are not found in other genes of this family, suggesting an evolutionary split between MKPs displaying specificity toward different MAP kinases. An intronless pseudogene is present on chromosome 10q11.2. Although 11p15.5 is an imprinted region, HB5 is almost entirely unmethylated on both alleles in lymphocytes. Chromosome 11p15 has been implicated in the development of a number of tumor types, including lung, a tissue known to express this gene. Loss of heterozygosity was found in one of eight informative lung tumors studied. |
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Authors:
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M A Nesbit; M D Hodges; L Campbell; T M de Meulemeester; M Alders; N R Rodrigues; K Talbot; A M Theodosiou; M A Mannens; Y Nakamura; P F Little; K E Davies |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genomics Volume: 42 ISSN: 0888-7543 ISO Abbreviation: Genomics Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-09-02 Completed Date: 1997-09-02 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 8800135 Medline TA: Genomics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 284-94 Citation Subset: IM |
Affiliation:
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Genetics Laboratory, Department of Biochemistry, University of Oxford, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Amino Acid Sequence Animals Base Sequence Calcium-Calmodulin-Dependent Protein Kinases / metabolism Chromosome Mapping Chromosomes, Human, Pair 10 / genetics* Chromosomes, Human, Pair 11 / genetics* Cloning, Molecular DNA Methylation DNA Primers / genetics DNA, Complementary / genetics, isolation & purification Exons Humans In Situ Hybridization, Fluorescence Introns Lung Neoplasms / genetics Mice Molecular Sequence Data Multigene Family Polymerase Chain Reaction Polymorphism, Genetic Protein Tyrosine Phosphatases / genetics*, metabolism Pseudogenes Substrate Specificity |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Complementary; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinases; EC 3.1.3.48/Protein Tyrosine Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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