Document Detail

Genomic multipotentiality of differentiated somatic cells.
MedLine Citation:
PMID:  3061587     Owner:  NLM     Status:  MEDLINE    
Nuclear transplantations from several differentiated somatic cell types into amphibian oocytes and eggs revealed that their genome contains the genes required for the development of prefeeding tadpoles. In addition, erythrocyte nuclei directed the formation of feeding tadpoles (independent organisms) that advanced to larval stages with hind limb buds. Thus, the genome of several differentiated somatic cell types can undergo widespread activation and specify a multiplicity of cell types. Although evidence for the genetic totipotency of differentiated somatic cells is lacking, we speculate that the genetic totipotency of at least some differentiated somatic cell types still remains a tenable hypothesis.
M A DiBerardino
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cell differentiation and development : the official journal of the International Society of Developmental Biologists     Volume:  25 Suppl     ISSN:  0922-3371     ISO Abbreviation:  Cell Differ. Dev.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8811335     Medline TA:  Cell Differ Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129.
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MeSH Terms
Cell Differentiation
Gene Expression Regulation*
Nuclear Transfer Techniques*
Oocytes / metabolism*
Grant Support

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